Microbiology Talk- MiTalk

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Episode 1- Hidden mechanisms for Biofilms against antibiotics

Episode 1- Hidden mechanisms for Biofilms against antibiotics

Recording Time: 26th July 2016; 8:00 pm IST

Topic: Biofilms and antibiotic resistance mechanism

Episode Highlights:

Basic understanding of biofilm

  • Structure of ¬†biofilm
  • Steps in a formation of a biofilm
  • Problems associated with biofilms in clinical settings

How a biofilm protects against antibiotics

  • Physical barrier
  • Efflux pump
  • Antibiotics as biofilm signals

Current state of research on drugs that can target biofilm

  • Anti-Biofilm strategies that are under investigation- Bactericidal strategies, anti adhesion strategies, Modulation of dispersing signals.
  • Acyldepsipeptides (ADEPs)

References and links:

  1. Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era. http://www.ncbi.nlm.nih.gov/pubmed/23545571
  2. Biofilms: Microbial Shelters Against Antibiotics. http://www.ncbi.nlm.nih.gov/pubmed/27214143
  3. Activated ClpP kills persisters and eradicates a chronic biofilm infection.http://www.ncbi.nlm.nih.gov/pubmed/24226776
  4. Strategies for combating bacterial biofilm infectionshttp://www.nature.com/ijos/journal/v7/n1/full/ijos201465a.html
  5. Polysaccharide-based antibiofilm surfaces. Acta Biomaterialiahttp://www.sciencedirect.com/science/article/pii/S1742706115301872
  6. BtB#8- Resistance, Persistence and Tolerance
  7. http://varuncnmicro.blogspot.in/2013/11/acyldepsipeptides-adeps-active-against.html
Updated: August 23, 2016 — 6:25 pm

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